Bolandiol
Prohormone of 19-nortestosterone (nandrolone) — converts in vivo to nandrolone via enzymatic oxidation. Marketed briefly as an OTC prohormone supplement in the late 1990s/2000s (as 19-norandrostenediol) following the DSHEA loophole era. Effects are those of nandrolone but attenuated by incomplete conversion.
Mechanism of Action
Functions as a pro-drug converted to nandrolone by 3β-HSD. Direct AR activity is minimal; effects are substantially mediated through the nandrolone metabolite. Low androgenicity from the 19-nor structure. Progestogenic activity via nandrolone conversion.
Typical Dosing
⚠ Warning Flags
- •Converts to nandrolone — doping positive up to 6+ months
- •WADA prohibited — supplements containing this caused mass inadvertent positives
Effect Profile
Side Effect Profile
Research Studies
Excretion of 19-norandrosterone after administration of 19-norandrostenediol in males
van Eenoo P, et al. · 2001
Oral 19-norandrostenediol (bolandiol) supplementation in male volunteers produced detectable urinary 19-norandrosterone (nandrolone metabolite) — demonstrating its conversion to nandrolone and causing inadvertent doping positives in athletes.