Drostanolone Enanthate
Long-ester version of Drostanolone (Masteron). A DHT derivative with anti-estrogenic properties, commonly used during contest prep for a hard, dry cosmetic look. Longer half-life than Masteron Propionate allows less frequent injections.
Mechanism of Action
DHT derivative that binds androgen receptors and exhibits anti-estrogenic activity. Does not aromatize into estrogen. May inhibit aromatase to some degree, reducing estrogen conversion from other aromatizing steroids in the stack. Primarily valued for its cosmetic muscle-hardening effect and mild strength gains. Targeted action on contractile tissue without water retention.
Typical Dosing
⚠ Warning Flags
- •Significant hair loss risk in those predisposed to androgenic alopecia
- •Lipid suppression — monitor HDL/LDL
- •Limited mass-building capacity — primarily a cosmetic/contest prep compound
- •No aromatization = requires a testosterone base for estrogen support
Effect Profile
Side Effect Profile
Research Studies
Drostanolone, an aromatase inhibitor, in the treatment of breast cancer in postmenopausal women
Chaudry MA et al. · 1985
Demonstrated Drostanolone's anti-estrogenic effect in clinical use for estrogen-receptor-positive breast cancer.
Anabolic steroids: an overview
Ganesan K et al. · 2021
Reviews the pharmacology of androgens including Drostanolone's hormonal modulation and tissue selectivity.
Structural characteristics of anabolic androgenic steroids contributing to binding to the androgen receptor
Fragkaki AG et al. · 2009
Confirms DHT derivatives like Drostanolone exhibit targeted androgen receptor binding profiles.