Mestanolone
17α-methylated dihydrotestosterone. Purely androgenic with only modest anabolic activity in muscle (like all DHT derivatives, it is inactivated by 3α-HSD in muscle). Historically used for hypogonadism in Germany (Ermalone). Produces pronounced strength and aggression effects with limited mass gains.
Mechanism of Action
Direct DHT derivative — cannot aromatize. Rapid inactivation by 3α-HSD in skeletal muscle limits anabolic effect. 17α-methylation provides oral activity but adds hepatotoxicity. Strong AR binding with primarily androgenic (CNS, aggression) output. Similar mechanistic profile to Proviron but more potent and more hepatotoxic.
Sourcing
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Typical Dosing
⚠ Warning Flags
- •Rarely available — significant counterfeiting risk
- •Hair loss acceleration (DHT-derived)
Effect Profile
Side Effect Profile
Research Studies
The effect of male hormone on the protein and energy metabolism of castrate dogs
Kochakian CD, Murlin JR. · 1936
Foundational nitrogen-balance studies establishing DHT-derived androgens' effects on protein metabolism; mestanolone's methylated DHT structure was characterized in follow-up work confirming its androgenic dominance over anabolic selectivity.