Methandriol
17α-methyl-5-androstene-3β,17β-diol — a testosterone and DHEA derivative used medically in the 1960s–1970s. Aromatizes to methylestradiol. Notable for a reported synergistic effect when combined with other AAS, though this claim lacks rigorous modern documentation. Rarely used today.
Mechanism of Action
AR agonist and partial aromatase substrate. 3β-diol structure means some conversion to more active androgens. 17α-methylation provides metabolic stability. The reported synergy with other AAS may relate to SHBG displacement and receptor sensitization but has not been rigorously characterized.
Sourcing
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Typical Dosing
⚠ Warning Flags
- •Largely obsolete — limited availability
- •Estrogenic due to aromatization
Effect Profile
Side Effect Profile
Research Studies
Steroids. XCI. 17-alkyl-modified 19-norsteroid derivatives
Ringold HJ, et al. · 1959
Original synthesis and Hershberger bioassay data for methandriol establishing its anabolic and androgenic potency relative to testosterone, forming the pharmacological basis for its clinical use.