Methandrostenolone
The original mass-builder. Extremely fast strength and size gains, significant water retention. The first synthetic AAS mass-produced for athletic performance. Liver toxic, highly estrogenic.
Mechanism of Action
High oral bioavailability due to 17α-alkylation. Aromatizes readily to methylestradiol (more potent than estradiol). Strong nitrogen retention. Rapid glycogen super-compensation explains fast initial strength gains.
Sourcing
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Typical Dosing
⚠ Warning Flags
- •17α-alkylated — hepatotoxic, limit to ≤6 weeks
- •Very high estrogen conversion — AI mandatory
- •Significant water retention obscures real gains
Effect Profile
Side Effect Profile
Research Studies
Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped
Forbes GB, et al. · 1992
Methandrostenolone and related androgens produced rapid but partly reversible increases in lean body mass, with nitrogen balance improvement documenting genuine anabolic effect.