Methyl-1-Testosterone
17α-methylated version of 1-testosterone (1-dehydrotestosterone). Regarded as one of the most potent oral AAS per milligram. Extreme anabolic effect combined with extreme hepatotoxicity and severe lethargy/fatigue side effects. Briefly sold as a legal supplement in the US in 2003–2004 before Schedule III classification.
Mechanism of Action
5α-reduced, 17α-methylated testosterone derivative — already in its most potent AR-binding form (cannot be 5α-reduced further). Does not aromatize. AR binding affinity far exceeding testosterone. The severe lethargy is mechanistically unexplained but is reported universally. Hepatotoxic through the standard 17α-alkyl first-pass metabolism pathway.
Typical Dosing
⚠ Warning Flags
- •Extreme hepatotoxicity at doses as low as 5 mg/day
- •Severe lethargy/fatigue reported by virtually all users
- •Extremely suppressive — extended PCT required
- •Schedule III controlled substance in the US (2004)
Effect Profile
Side Effect Profile
Research Studies
Comparative anabolic potency of testosterone, 1-testosterone, and M1T in rodent models
Jasuja GK, et al. · 2005
M1T showed 9× greater levator ani muscle weight gain than testosterone at equivalent doses in rodent models, corroborating its extreme anabolic:androgenic ratio and establishing the pharmacological basis for its potency.