Mibolerone
An extremely potent oral androgen originally developed as a veterinary drug to suppress estrus in dogs. Used by some powerlifters and fighters pre-competition for its powerful CNS-stimulating aggression effects. One of the most hepatotoxic steroids in existence — extremely dangerous with very limited practical application.
Mechanism of Action
Extremely potent androgen receptor agonist — one of the strongest known synthetic androgens. Produces intense CNS stimulation and aggression via androgen receptor activation in the brain. Also a potent progestogen. Despite an astronomical anabolic ratio on paper, its practical muscle-building utility is severely limited by its extreme hepatotoxicity which precludes use beyond very short durations (minutes to hours pre-event).
Typical Dosing
⚠ Warning Flags
- •EXTREME hepatotoxicity — one of the most liver-toxic steroids known
- •Veterinary drug — not designed for human use
- •Extreme aggression and CNS effects
- •Progestogenic — can cause gynecomastia
- •Essentially zero practical muscle-building utility — only used pre-event for aggression
- •Should never be used for more than hours at a time
Effect Profile
Side Effect Profile
Research Studies
Pharmacological and endocrinological studies on anabolic agents
Neumann F · 1976
Characterized mibolerone as among the most potent synthetic androgens with extreme androgenic:anabolic dissociation.
Behavioral and physiological responses to anabolic-androgenic steroids
Clark AS, Henderson LP · 2003
Documents the neurological effects of potent androgens including aggression, anxiety, and CNS activation patterns.
Pharmacology of anabolic steroids
Kicman AT · 2008
Reviews the pharmacology of synthetic androgens including structure-activity relationships of potent compounds like mibolerone.