Nandrolone Decanoate
One of the most studied synthetic AAS. Highly anabolic, low androgenic. Excellent for joint health and lean mass. Very suppressive. Famous 'Deca Dick' risk from prolactin/progestin activity.
Mechanism of Action
Binds AR with high affinity. 5α-reduces to dihydronandrolone (much weaker than DHT, minimizing androgenic scalp/skin effects). Does NOT aromatize significantly but has progestogenic activity — raises prolactin, suppresses LH/FSH more potently than testosterone.
Typical Dosing
⚠ Warning Flags
- •High prolactin risk — use cabergoline on-cycle
- •Very long clearance time (up to 18 months detectable)
- •'Deca Dick' (sexual dysfunction) risk if not paired with sufficient testosterone
Effect Profile
Side Effect Profile
Research Studies
The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis
Frisoli A Jr, et al. · 2005
Nandrolone decanoate significantly increased bone density and lean mass in elderly women, demonstrating potent anabolic effects with minimal androgenic side effects.
Anabolic effects of nandrolone decanoate in patients receiving dialysis
Johansen KL, et al. · 1999
Dialysis patients receiving nandrolone showed significant increases in lean body mass and muscle strength, validating its anti-catabolic and anabolic properties.
Anabolic effects of low dose nandrolone decanoate in HIV-positive men
Brodsky IG, et al. · 1996
Low-dose nandrolone significantly improved nitrogen retention and lean mass in HIV+ patients, confirming its potent anabolic-to-androgenic ratio advantage.