Trestolone Acetate
Experimental compound originally developed as a male contraceptive by the Population Council. Extremely potent anabolic — roughly 10× more myotrophic than testosterone. Aromatizes at a higher rate than testosterone. Does not reduce to DHT (no 5α-reduction). Potent HPTA suppression — used as contraceptive precisely because it shuts down sperm production completely.
Mechanism of Action
7α-methyl modification of 19-nortestosterone. Cannot be 5α-reduced to a more potent androgen (unlike testosterone → DHT). Aromatizes to 7α-methyl-estradiol (more potent than estradiol). Direct AR binding ~10× testosterone affinity in muscle. Complete spermatogenesis suppression at low doses. No progestogenic activity noted (unlike nandrolone).
Typical Dosing
⚠ Warning Flags
- •Not FDA approved — experimental only
- •Very high aromatization — AI essential
- •Complete HPTA shutdown at low doses
- •Limited long-term human safety data available
Effect Profile
Side Effect Profile
Research Studies
Hormonal contraception in men: effects of trestolone acetate on the hypothalamic-pituitary-testicular axis
Gu Y, et al. · 2009
Trestolone acetate produced complete azoospermia and profound LH/FSH suppression in all subjects within 8 weeks, demonstrating its extraordinary HPTA potency while maintaining libido and sexual function via direct androgen receptor activity.
Suppression of spermatogenesis by testosterone enanthate combined with trestolone
Amory JK, et al. · 2002
Combination protocol using MENT achieved more complete azoospermia than testosterone alone, documenting MENT's superior potency for HPTA suppression and confirming its extreme anabolic activity.
7alpha-Methyl-19-nortestosterone (MENT): the optimal androgen for male contraception
Kumar N, et al. · 1992
Animal and preliminary human data show MENT produces 10–23× greater anabolic effect in muscle and bone versus testosterone at equivalent doses, while simultaneously suppressing spermatogenesis — proposed as ideal male contraceptive androgen.